diff --git a/Modules/_ssl.c b/Modules/_ssl.c
index f70af266731ad0..8897c6a4516efa 100644
--- a/Modules/_ssl.c
+++ b/Modules/_ssl.c
@@ -2048,7 +2048,7 @@ static PyMethodDef PySSLMethods[] = {
      PySSL_peercert_doc},
     {"cipher", (PyCFunction)PySSL_cipher, METH_NOARGS},
     {"version", (PyCFunction)PySSL_version, METH_NOARGS},
-#ifdef OPENSSL_NPN_NEGOTIATED
+#if defined(OPENSSL_NPN_NEGOTIATED) && !defined(OPENSSL_NO_NEXTPROTONEG)
     {"selected_npn_protocol", (PyCFunction)PySSL_selected_npn_protocol, METH_NOARGS},
 #endif
 #ifdef HAVE_ALPN