diff --git a/Lib/test/test_peg_generator/test_c_parser.py b/Lib/test/test_peg_generator/test_c_parser.py
index 0dffedca789c57..b4145bb7799f26 100644
--- a/Lib/test/test_peg_generator/test_c_parser.py
+++ b/Lib/test/test_peg_generator/test_c_parser.py
@@ -1,3 +1,4 @@
+import sysconfig
 import textwrap
 import unittest
 from distutils.tests.support import TempdirManager
@@ -8,6 +9,10 @@
 from test.support import os_helper
 from test.support.script_helper import assert_python_ok
 
+_pyflags_nodist = sysconfig.get_config_var('PY_CFLAGS_NODIST') or ()
+if sysconfig.get_config_var('PGO_PROF_USE_FLAG') in _pyflags_nodist:
+    raise unittest.SkipTest("peg_generator test disabled when building with PGO")
+
 test_tools.skip_if_missing("peg_generator")
 with test_tools.imports_under_tool("peg_generator"):
     from pegen.grammar_parser import GeneratedParser as GrammarParser